Hydroxycinnamic acid - a natural barrier to prevent and protect free radicals

Vitamins, Fe2+, and Cu2+ are ubiquitous in organisms. The Fenton reaction produces oxygen radicals in the process of aerobic metabolism. Hydroxyl radicals (•OH) are the most active, most toxic and harmful in human active oxygen radicals. The largest free radical, which can cause oxidative damage and destruction of sugars, amino acids, proteins, nucleic acids and other substances in tissues, and cause cell necrosis or mutation. In the process of aerobic metabolism, cells can produce OH in many ways. When the body is cleared of OH, when the active substance is insufficient, accumulation of OH can directly cause destruction of cell membranes, DNA, and other biological macromolecules and cause a series of difficult diseases such as heart disease, Alzheimer's disease and Parkinson's disease. Therefore, the study of OH scavengers is of great practical significance.

Recently, the Department of Chemistry of the Medical College of Shantou University has been experimentally determined to use a p-hydroxycinnamic acid derivative in comparison with the effects of 3-OH, 2-OCH3, and 4-OCH3 used in previous tests to remove OH in vitro. The relatively clear and relatively strong ability to remove OH activity has a good preventive and protective effect on some free radical-induced lesions and injuries, effectively reducing the chance of free radicals causing difficult diseases. The use of p-hydroxycinnamic acid as a scavenger of •OH, its own biological activity, strong in anti-oxidation, anti-tumor, anti-chemotherapy, etc., also applies to other medical biological research, in the prevention and treatment of free radical lesions There has been a further breakthrough.