Na + -K + pump - actually Na + -K + ATPase exists in the plasma membrane of animal and plant cells, it has the size of two subunits, large subunit catalytic ATP hydrolysis, the small subunit is a glycoprotein.Na + - K + ATPase undergoes conformational changes through phosphorylation and dephosphorylation, resulting in changes in affinity with Na +, K +. Large subunit to Na + state Na + binding Na, trigger hydrolysis of ATP. The energy released by the release of one ATP per hydrolysis delivers 3 Na + to the extracellular and 2 K + into the cell at the same time, resulting in a transmembrane gradient and potential difference that is particularly important for nerve impulse conduction. The membrane potential difference caused by Na + -K + pump accounts for about If the purified Na + -K + pump is assembled on the erythrocyte membrane vesicles (blood shadow), artificially increase the Na +, K + gradient on both sides of the membrane to a certain extent, when the energy held by the gradient When greater than the chemical energy of ATP hydrolysis, Na +, K + will reverse cis concentration flow Na + -K + pump, while the synthesis of ATP. One of the hallmarks of the sodium-potassium pump is that he relies on an autophosphorylation cycle in which the ion is transported. A phosphate group on the ATP shifts to an aspartate residue in the sodium-potassium pump, resulting in conformational changes. Ion pumps that transport ions by autophosphorylation are called P-type, and similarly calcium and proton pumps. They make up a family of proteins that are functionally and structurally similar. Na + -K + pump role is: â‘ maintain cell permeability, maintain the volume of cells; â‘¡ maintain low Na + high K + intracellular environment, to maintain cell resting potential. Ouabain and digoxin can inhibit the activity of Na + -K + pump in cardiomyocytes, thereby reducing the efficiency of sodium-calcium exchanger, increasing the influx of calcium ions and enhancing myocardial contractility, thus having a cardiac effect .
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